{"id":1843,"date":"2021-08-27T20:38:08","date_gmt":"2021-08-27T20:38:08","guid":{"rendered":"http:\/\/janellesante.com\/ingredients\/"},"modified":"2021-08-27T20:38:08","modified_gmt":"2021-08-27T20:38:08","slug":"ingredients","status":"publish","type":"page","link":"https:\/\/janellesante.com\/en\/ingredients\/","title":{"rendered":"Ingredients"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1843\" class=\"elementor elementor-1843 elementor-302\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-db2166a elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"db2166a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-217427a\" data-id=\"217427a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-01d30bf elementor-widget elementor-widget-image\" data-id=\"01d30bf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1\" height=\"1\" src=\"https:\/\/janellesante.com\/wp-content\/uploads\/2021\/05\/Icon_JanelleSante.svg\" class=\"attachment-large size-large wp-image-86\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9e1e637 elementor-widget elementor-widget-heading\" data-id=\"9e1e637\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Ingredients<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-34d6915 elementor-widget elementor-widget-heading\" data-id=\"34d6915\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Our medicinal ingredients<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e9e3cc8\" data-id=\"e9e3cc8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-519a4b1 elementor-widget elementor-widget-image\" data-id=\"519a4b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"585\" height=\"443\" src=\"https:\/\/janellesante.com\/wp-content\/uploads\/2021\/05\/Header_IngredientsMedicinaux.png\" class=\"attachment-large size-large wp-image-306\" alt=\"\" srcset=\"https:\/\/janellesante.com\/wp-content\/uploads\/2021\/05\/Header_IngredientsMedicinaux.png 585w, https:\/\/janellesante.com\/wp-content\/uploads\/2021\/05\/Header_IngredientsMedicinaux-300x227.png 300w\" sizes=\"(max-width: 585px) 100vw, 585px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-35c9aac elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"35c9aac\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-8a31632\" data-id=\"8a31632\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27f4973 elementor-widget elementor-widget-heading\" data-id=\"27f4973\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Ingredients<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b25f79e elementor-widget elementor-widget-text-editor\" data-id=\"b25f79e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Capsaicine \/ Cayenne Capsicum annuum (0,75%)<br \/><\/strong>Capsaicin works as an analgesic. It activates the production of substance P, which itself triggers the sensation of pain during an injury, hence the initial burning sensation. When the supply of substance P is depleted, the nerve endings can no longer communicate pain for a long period.<\/p>\n<p><strong>Huile d\u2019Arnica (5%)<br \/><\/strong>Arnica has analgesic, anti-inflammatory, healing and circulatory properties. Arnica\u2019s primary function is anti-inflammatory. Indeed, sesquiterpene lactones are capable of inhibiting the oxidative phosphorylation of polynuclear cells as well as their migration. These molecules also prevent the rupture of the lysosomal membranes, thereby preserving the cell integrity. They have an anti-ecchymotic action associated with the inhibition of platelet aggregation. Finally, Arnica could also have analgesic properties.<\/p>\n<p><strong>Menthol (10%)<br \/><\/strong>Pain-relieving and anti-inflammatory properties. Just like the application of ice on skin (or cryotherapy), menthol activates the skin thermoreceptors, which creates freshness sensation and deep analgesia. The thermoreceptors involved are the TRPM8 receptors sensitive to cold temperatures. Those are involved in the processess of inflammation, pain and itching (pruritus).<\/p>\n<p><strong>Dichlorhydrate d\u2019histamine (0,025%)<br \/><\/strong>Histamine dihydrochloride, helps alleviate pain. Once absorbed into the skin, it acts as a vasodilator, temporarily increasing the size of your blood vessels for greater circulation. This action safely and effectively reduces pain in the joint or muscle. This approved active ingredient is derived from histamine, an organic compound produced by your body.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-66 elementor-top-column elementor-element elementor-element-3343731\" data-id=\"3343731\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-09be3fe elementor-widget elementor-widget-heading\" data-id=\"09be3fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Bibliography<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1189edd elementor-widget elementor-widget-text-editor\" data-id=\"1189edd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Capsa\u00efcine \/ Cayenne Capsicum annuum<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/arthrite.ca\/traitement\/medicaments\/guide-des-medicaments\/medications\/capsaicine\">Capsa\u00efcine \/ Cayenne Capsicum annuum<\/a>,<br \/>Soci\u00e9t\u00e9 de l\u2019arthrite du Canada,<\/li>\n<li><a href=\"https:\/\/janellesante.com\/ingredients\/www.arc.org.uk\">Arthritis Research Campaign. Complementary and alternative medicines for the treatment of rheumatoid arthritis, osteoarthritis and fibromyalgia,<\/a>  2008.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20446852\">Topical capsaicin. The fire of a \u2018hot\u2019 medicine is reignited.<\/a> Expert Opin Pharmacother. 2010 Jun;11(8):1359-71. doi: 10.1517\/14656566.2010.481670.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31519301\">Capsaicin topical cream (8%) for the treatment of myofascial pain syndrome.<\/a> Rev Bras Anestesiol. 2019 Sep \u2013 Oct;69(5):432-438. doi: 10.1016\/j.bjan.2019.06.008. Epub 2019 Sep 10<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18209521\">Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival?<\/a> Clin J Pain. 2008 Feb;24(2):142-54. doi: 10.1097\/AJP.0b013e318158ed9e.<\/li>\n<li><a href=\"https:\/\/janellesante.com\/ingredients\/www.consumerlab.com\">The Natural Pharmacist (Ed). Natural Products Encyclopedia, Herbs &amp; Supplements \u2013 Cayenne<\/a><\/li>\n<li><a href=\"https:\/\/janellesante.com\/ingredients\/www.naturaldatabase.com\">Therapeutic Research Faculty (Ed). Capsicum, Natural Medicines Comprehensive Database.<\/a><\/li>\n<li><a href=\"https:\/\/janellesante.com\/ingredients\/www.pharmasante.org\">Les autres cr\u00e8mes anesth\u00e9siantes<\/a><br \/><a href=\"https:\/\/janellesante.com\/ingredients\/www.neurologies.fr\">La capsa\u00efcine \u00e0 haute concentration<\/a>, (2011)<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19821411\">Topical capsaicin for chronic neuropathic pain in adults.<\/a> Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007393. doi: 10.1002\/14651858.CD007393.pub2.<\/li>\n<\/ul>\n<p><strong>Arnica<\/strong><\/p>\n<ul>\n<li>Arnica montana L. \u2013 a plant of healing: review. J Pharm Pharmacol. 2017 Aug;69(8):925-945. doi: 10.1111\/jphp.12724. Epub 2017 Apr 11.<br \/>Barnes Joan, Anderson A. Linda, Phillipson David J. Herbal Medicines, Pharmaceutical Press, Grande-Bretagne, 2002, 2e \u00e9dition.<\/li>\n<li>Anti-inflammatory and immune-regulatory mechanisms prevent contact hypersensitivity to Arnica Montana. Christian Lass L et al,<br \/>Experimental Dermatology, 17:849\u2013857. 2008.<\/li>\n<li>The Anti-inflammatory Sesquiterpene Lactone Helenalin Inhibits. The Transcription Factor NF-kB by Directly Targeting p65. Guido<br \/>Ly\u00df et al, The journal of Biological chemistry, 273(50):33508\u201333516. 1998.<\/li>\n<li>Helenalin and 11\u03b1,13-dihydrohelenalin, two constituents from Arnica Montana L., inhibit human platelet function via thiol-dependent<br \/>pathways. Schroder H et al. Thromb Res, 57: 839-845. 1990<\/li>\n<li>European Scientific Cooperative on Phytotherapy (Ed). Arnicae flos, ESCOP Monographs on the Medicinal Uses of Plants Drugs, Centre for Complementary Health Studies, Universit\u00e9 d\u2019Exeter, Grande-Bretagne, 1997.<\/li>\n<li><a href=\"https:\/\/janellesante.com\/ingredients\/www.naturalstandard.com\">Natural Standard (Ed). Herbs &amp; Supplements \u2013 Arnica, Nature Medicine Quality Standard.<\/a><\/li>\n<\/ul>\n<p><strong>Menthe poivr\u00e9e<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29524352\">The role and mechanism of action of menthol in topical analgesic products.<\/a> J Clin Pharm Ther. 2018 Jun;43(3):313-319. doi: 10.1111\/jcpt.12679. Epub 2018 Mar 10.<br \/><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18930858\">Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels.<\/a> Pak J Pharm Sci. 2008 Oct;21(4):370-8.<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15363396\">The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron.<\/a> 2004 Sep 16;43(6):859-69.<\/li>\n<li><a href=\"https:\/\/www.fda.gov\/downloads\/Drugs\/DevelopmentApprovalProcess\/DevelopmentResources\/Over-the-CounterOTCDrugs\/StatusofOTCRulemakings\/UCM077928.pdf\">Dichlorhydrate d\u2019histamine<\/a><\/li>\n<li><a href=\"https:\/\/www.drugbank.ca\/salts\/DBSALT002193\">https:\/\/www.drugbank.ca\/salts\/DBSALT002193<\/a><\/li>\n<li><a href=\"https:\/\/doi.org\/10.1038\/sj.bjc.6603461\">Brunstein, F., Rens, J., van Tiel, S. et al. Histamine, a vasoactive agent with vascular disrupting potential, improves tumour response by enhancing local drug delivery.<\/a> Br J Cancer 95, 1663\u20131669 (2006).<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Ingredients Our medicinal ingredients Ingredients Capsaicine \/ Cayenne Capsicum annuum (0,75%)Capsaicin works as an analgesic. It activates the production of substance P, which itself triggers the sensation of pain during an injury, hence the initial burning sensation. When the supply of substance P is depleted, the nerve endings can no longer communicate pain for a &#8230; <a title=\"Ingredients\" class=\"read-more\" href=\"https:\/\/janellesante.com\/en\/ingredients\/\" aria-label=\"Read more about Ingredients\">Read more<\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1843","page","type-page","status-publish"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ingredients - Janelle Sant\u00e9<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/janellesante.com\/en\/ingredients\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ingredients - Janelle Sant\u00e9\" \/>\n<meta property=\"og:description\" content=\"Ingredients Our medicinal ingredients Ingredients Capsaicine \/ Cayenne Capsicum annuum (0,75%)Capsaicin works as an analgesic. 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It activates the production of substance P, which itself triggers the sensation of pain during an injury, hence the initial burning sensation. When the supply of substance P is depleted, the nerve endings can no longer communicate pain for a ... 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