Ingredients
Our medicinal ingredients
Ingredients
Capsaicine / Cayenne Capsicum annuum (0,75%)
Capsaicin works as an analgesic. It activates the production of substance P, which itself triggers the sensation of pain during an injury, hence the initial burning sensation. When the supply of substance P is depleted, the nerve endings can no longer communicate pain for a long period.
Huile d’Arnica (5%)
Arnica has analgesic, anti-inflammatory, healing and circulatory properties. Arnica’s primary function is anti-inflammatory. Indeed, sesquiterpene lactones are capable of inhibiting the oxidative phosphorylation of polynuclear cells as well as their migration. These molecules also prevent the rupture of the lysosomal membranes, thereby preserving the cell integrity. They have an anti-ecchymotic action associated with the inhibition of platelet aggregation. Finally, Arnica could also have analgesic properties.
Menthol (10%)
Pain-relieving and anti-inflammatory properties. Just like the application of ice on skin (or cryotherapy), menthol activates the skin thermoreceptors, which creates freshness sensation and deep analgesia. The thermoreceptors involved are the TRPM8 receptors sensitive to cold temperatures. Those are involved in the processess of inflammation, pain and itching (pruritus).
Dichlorhydrate d’histamine (0,025%)
Histamine dihydrochloride, helps alleviate pain. Once absorbed into the skin, it acts as a vasodilator, temporarily increasing the size of your blood vessels for greater circulation. This action safely and effectively reduces pain in the joint or muscle. This approved active ingredient is derived from histamine, an organic compound produced by your body.
Bibliography
Capsaïcine / Cayenne Capsicum annuum
- Capsaïcine / Cayenne Capsicum annuum,
Société de l’arthrite du Canada, - Arthritis Research Campaign. Complementary and alternative medicines for the treatment of rheumatoid arthritis, osteoarthritis and fibromyalgia, 2008.
- Topical capsaicin. The fire of a ‘hot’ medicine is reignited. Expert Opin Pharmacother. 2010 Jun;11(8):1359-71. doi: 10.1517/14656566.2010.481670.
- Capsaicin topical cream (8%) for the treatment of myofascial pain syndrome. Rev Bras Anestesiol. 2019 Sep – Oct;69(5):432-438. doi: 10.1016/j.bjan.2019.06.008. Epub 2019 Sep 10
- Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival? Clin J Pain. 2008 Feb;24(2):142-54. doi: 10.1097/AJP.0b013e318158ed9e.
- The Natural Pharmacist (Ed). Natural Products Encyclopedia, Herbs & Supplements – Cayenne
- Therapeutic Research Faculty (Ed). Capsicum, Natural Medicines Comprehensive Database.
- Les autres crèmes anesthésiantes
La capsaïcine à haute concentration, (2011) - Topical capsaicin for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007393. doi: 10.1002/14651858.CD007393.pub2.
Arnica
- Arnica montana L. – a plant of healing: review. J Pharm Pharmacol. 2017 Aug;69(8):925-945. doi: 10.1111/jphp.12724. Epub 2017 Apr 11.
Barnes Joan, Anderson A. Linda, Phillipson David J. Herbal Medicines, Pharmaceutical Press, Grande-Bretagne, 2002, 2e édition. - Anti-inflammatory and immune-regulatory mechanisms prevent contact hypersensitivity to Arnica Montana. Christian Lass L et al,
Experimental Dermatology, 17:849–857. 2008. - The Anti-inflammatory Sesquiterpene Lactone Helenalin Inhibits. The Transcription Factor NF-kB by Directly Targeting p65. Guido
Lyß et al, The journal of Biological chemistry, 273(50):33508–33516. 1998. - Helenalin and 11α,13-dihydrohelenalin, two constituents from Arnica Montana L., inhibit human platelet function via thiol-dependent
pathways. Schroder H et al. Thromb Res, 57: 839-845. 1990 - European Scientific Cooperative on Phytotherapy (Ed). Arnicae flos, ESCOP Monographs on the Medicinal Uses of Plants Drugs, Centre for Complementary Health Studies, Université d’Exeter, Grande-Bretagne, 1997.
- Natural Standard (Ed). Herbs & Supplements – Arnica, Nature Medicine Quality Standard.
Menthe poivrée
- The role and mechanism of action of menthol in topical analgesic products. J Clin Pharm Ther. 2018 Jun;43(3):313-319. doi: 10.1111/jcpt.12679. Epub 2018 Mar 10.
Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Pak J Pharm Sci. 2008 Oct;21(4):370-8. - The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron. 2004 Sep 16;43(6):859-69.
- Dichlorhydrate d’histamine
- https://www.drugbank.ca/salts/DBSALT002193
- Brunstein, F., Rens, J., van Tiel, S. et al. Histamine, a vasoactive agent with vascular disrupting potential, improves tumour response by enhancing local drug delivery. Br J Cancer 95, 1663–1669 (2006).
